Excess PGE2 was the culprit behind my mysterious post partum weight gain. PGE2 or Prostaglandin E2 is an inflammatory molecule that inhibits fat burning and increases pain, swelling, inflammation, redness, fatigue, allergies and estrogen. My hormones were imbalanced or "Estrogen Dominant" because of PGE-2. When PGE2 is high it signals our fat cells to actually stop Lipolysis or "Fat Burning" and also increases estrogen production.
PGE2 is what was making me unable to lose my post partum baby weight because until I switched my diet to reduce my levels of PGE-2 my weight, pain and fatigue cluster would not improve. Paying attention to PGE-2 was and still is necessary for me personally to feel good and have pain free days.
If you are struggling to lose weight AND also have swelling, pain, arthritis, headaches and other signs of PGE-2 elevation then you most likely have persistently elevated levels of PGE-2 inhibiting your fat burning potential. We can work together on diet and lifestyle modifications to lower your PGE-2 and unplug or unclog your metabolism.
Is Prostaglandin E2 a Weight Loss Hormone?
While I think of PGE-2 as a hormone being a “Hormone Doctor” PGE-2 is technically not a hormone as it is not made by a specific gland, but as a prostaglandin it does have the capacity to act in a multi-factorial manner very similar to how a hormone works. The purpose of PGE-2 is to cause swelling during an injury or infection which brings more blood flow to an affected area so it can be healed.
When PGE-2 remains constantly elevated the body continues to swell and inflammation now impedes fat burning. Lets think of PGE-2 as the evil person that goes in to your fat cells and flips the fat burning switch to OFF.
I don't know about you...but I want to be burning as much fat as I possibly can at all times!
But when our PGE-2 Levels are high and we are inflamed we are not burning fat at our true metabolic potential. Our thyroid and other metabolic hormones could all look perfect on paper yet we still struggle to have that perfect metabolism. PGE-2 tells the body "We are on fire and in an emergency state." When you are on fire you don't care about weight loss or fat burning. Your primary concern is putting out the fire.
PGE-2 in my mind is the “Missing Weight Loss Mystery Hormone” when all my patient’s other hormones are PERFECT yet they still cannot release the weight.
What is PGE-2?
I jokingly refer to Prostaglandin E2 as the “Annoying Red Headed Step Child” of the Hormonal Weight Loss World. PGE-2 IS the more annoying and less thought about cause of weight gain and hormone imbalance. While PGE-2 is not the MOST popular weight loss hormone we think of such as TSH in Hypothyroidism, PGE-2 is still an ANNOYING AND FRUSTRATING little known cause of weight gain that many of my patients suffer from and cannot get under control without a targeted program designed specifically to address and lower the abnormally high PGE-2 levels. Especially when combined with other metabolic issues such as Metabolic Syndrome, Prediabetes, Insulin Resistance and Estrogen Dominance. PGE-2 is also the Mother of Estrogen Dominance and therefore an important "Hormone" that we address to keep our hormones in proper balance and prevent breast cancer.
But just like the “Annoying Red Headed Step Child,” PGE2 will also keep screaming in your face until you decide to pay attention to it and get it under control.
HOW CAN WE SILENCE THE SCREAMING PGE2 CHILD?
When you place your hand over a screaming child’s mouth you can succeed in getting them to temporarily stop screaming.
Top Sources of PGE-2
1. Foods Allergies & Food Intolerances
2. Arachidonic Acid
3. Too Much Omega-6
BUT WHAT HAPPENS WHEN WE TAKE OUR HAND OFF?
The child will just SCREAM LOUDER! Therefore we can conclude that putting your hand over a screaming child’s mouth does not stop their screaming and it may even get you kicked. Any attempts to suppress the screaming will just result in MORE SCREAMING!
When I was eating toddler foods and party foods and not following my gluten free low PGE-2 Diet I was suppressing my fat cells from burning fat while also driving up my estrogen dominance pushing my Post Partum hormones further out of balance.
Just like any WRONG ATTEMPTS to lose weight when we ignore PGE-2 will just result in MORE WEIGHT GAIN BACK when we stop our latest WRONG ATTEMPT plus a “Kick” in the form of a handful of other PGE-2 related problems like migraines, stomachaches, fatigue, arthritis, depression and anxiety.
Instead of telling PGE-2 to SHUT UP we need to calm it down and soothe it in the same manner we would an angry child. We need to LISTEN TO and try to UNDERSTAND where our PGE-2 is coming from! You can learn how to eliminate PGE-2 from your diet by signing up for my FREE GUIDE "The PGE-2 Diet: Lower Your PGE-2 to Lose Weight, Reduce Pain and Boost Mood"
Purchase your Food Allergy Intolerance Test or Package Below.
If you feel like your PGE2 and Metabolic hormones are out of balance, have pain, cramps, stomach aches, allergies, skin problems, depression, anxiety and mood issues please call to schedule an appointment (480) 837-0900 or schedule your appointment or Food Allergy Intolerance Testing Below.
Dr. Nicole Sundene
Is a Naturopathic Medical Doctor in Scottsdale, AZ with over 20 years of experience serving patients in health care. She worked in Traditional Family Medicine from 1999-2007 and since 2007 has worked as a Naturopathic Doctor. As a result of her diverse experience she practices an integrated style of medicine using herbs and supplements before prescribing medications. She is considered a leading expert in the Naturopathic field of Women's Health and how it pertains to Gynecology, Mental Health and Endocrinology. She enjoys the challenge involved in solving complex chronic disease and hormonal health problems with the least amount of prescription medications necessary.